File:Mechanisms of VSG switching2.png
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Summary
| Description |
English: Mechanisms of VSG switching in T. brucei:
A. Structure of the expression site including the expression site associated genes (ESAG), 70 base pair repeat up-stream sequence, expressed VSG gene, and the telomere B. Mechanism of array VSG conversion: A silent VSG is copied from a subtelomeric VSG array into an ES, where it replaces the active VSG. C. Telomeric VSG conversion: A telomeric VSG (including 70 bp repeat sequence upstream and telomere downstream) replaces the active VSG in the ES D. Segmental VSG conversion: Sequence is copied from multiple inactive VSG genes and combined into a novel mosaic VSG that occupies the ES E. Transcriptional VSG switching: A non-recombination based mechanism that activates a new (previously silent) ES, while inactivating the previously active ES. |
| Date | |
| Source | Adapted from: PLoS Biol. 2008 Jul 29;6(7):e185. |
| Author | Chris Stockdale, Michal R. Swiderski, J. David Barry, Richard McCulloch |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 14:49, 6 May 2011 | | 1,498 × 738 (504 KB) | 2011MMG320group1 | {{Information |Description ={{en|1= Mechanisms of VSG switching in T. brucei: A. Structure of the expression site including the expression site associated genes (ESAG), 70 base pair repeat up-stream sequence, expressed VSG gene, and the telomere B. Me |
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